About VIMOVO — A SMART Choice

VIMOVO contains naproxen, an NSAID that relieves symptoms of arthritis, and esomeprazole magnesium, a proton pump inhibitor that reduces risks of stomach ulcers from naproxen

Taking high-dose naproxen alone dramatically increases your risk of stomach ulcers 1

If you have osteoarthritis, rheumatoid arthritis or ankylosing spondylitis pain, you have likely been recommended or treated with NSAIDs (nonsteroidal anti-inflammatory drugs), such as naproxen, to help relieve the pain and inflammation.

Without treatment, even everyday activities can be difficult because your joints are painful or stiff.2 NSAIDs may provide effective arthritis pain relief, but they may also come with a side effect of stomach ulcers.

  • An ulcer is an open sore in the lining of your stomach or esophagus, caused by acidic digestive juices “burning” a hole in the lining.3

VIMOVO is the smarter naproxen because it offers gastroprotection

VIMOVO ("vi-moh'-voh") is an FDA-approved prescription combination medication that relieves arthritis pain and offers gastroprotection to help reduce the risk of stomach problems related to naproxen use.5 VIMOVO combines both:

  • Naproxen, one of the most commonly used NSAIDs, to relieve pain and swelling
  • Esomeprazole, to protect your stomach. It is a commonly used PPI, which reduces the production of acid by blocking the enzyme in the wall of the stomach that produces acid. The reduction of acid reduces the risk of ulcers.6

Ask Your Doctor If VIMOVO Is Right for You

If you're feeling limited by arthritis pain, ask your doctor if VIMOVO may help you get back to the everyday activities you enjoy—with less risk of NSAID stomach ulcers.

VIMOVO is not recommended as a starting treatment for relief of acute pain. Controlled studies do not extend beyond 6 months.4


  • VIMOVO is contraindicated in patients with known hypersensitivity to any component of VIMOVO or substituted benzimidazoles; in patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs; in patients during the perioperative period in the setting of coronary artery bypass graft (CABG) surgery; or in patients in the late stages of pregnancy
  • Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals

Access the Doctor Discussion Guide


  1. Lanza FL, Chan FKL, Quigley EMM. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009;104:728-738.
  2. Osteoarthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. http://www.niams.nih.gov/Health_info/Osteoarthritis/default.asp. Accessed May 22, 2014.
  3. Marks JW. Peptic ulcer. Medicine Net website. http://www.medicinenet.com/peptic_ulcer/page2.htm#what_is_a_peptic_ulcer. Accessed June 19, 2015.
  4. Larkai EN, Smith JL, Lidsky MD, Graham DY. Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use. Am J Gastroenterol. 1987;82:1153-1158.
  5. VIMOVO (naproxen/esomeprazole magnesium) [package insert]. Deerfield, IL: Horizon Pharma Inc; December 2014.
  6. Ogbru O. Proton-pump inhibitors (PPIs). Medicine Net website. http://www.medicinenet.com/proton-pump_inhibitors/article.htm. Accessed June 19, 2015.
  7. Goldstein JL, Hochberg MC, Fort JG, Zhang Y, Hwang C, Sostek M. Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs enteric-coated naproxen alone. Aliment Pharmacol Ther. 2010;32:401-413.