How to Take VIMOVO

How to take VIMOVO (naproxen/esomeprazole magnesium), twice-daily osteoarthritis treatment

VIMOVO is a twice-a-day1 prescription medication for osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis treatment. Take 1 VIMOVO pill at night and 1 pill the next morning.

VIMOVO may help reduce the pain and inflammation caused by OA/RA/AS while helping to reduce the risk of stomach ulcers common in those taking NSAIDs.1

Taking VIMOVO With Low-dose Aspirin

If you take low-dose aspirin (less than 325 mg/day) and also need to take a high-dose NSAID for arthritis pain, VIMOVO may be a good option for you and your doctor to consider.1

However, it's important to be aware that all prescription NSAIDs, including VIMOVO, may increase the chance of heart attack or stroke, which can lead to death.1
Taking low-dose aspirin may not reduce this risk,1 and you should never use VIMOVO as a substitute for aspirin in preventing heart attack or stroke. Taking aspirin and an NSAID may increase your risk of side effects, including serious ones.1 Tell your doctor if you take aspirin.

Concomitant administration of naproxen and aspirin is not generally recommended because of the potential of increased adverse events.

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious cardiovascular thrombotic events associated with NSAID use.

Following Your Doctor’s Instructions

  • Take VIMOVO exactly as your doctor tells you to take it
  • Take VIMOVO at least 30 minutes before a meal1
  • Swallow VIMOVO tablets whole with liquid. Do not split, chew, crush, or dissolve the VIMOVO tablet1
  • Tell your doctor if you cannot swallow the tablet whole—you may need a different medicine
  • Your doctor may tell you to take vitamin D and calcium supplements during treatment with VIMOVO1
  • Your doctor will tell you how many VIMOVO tablets to take and when to take them
  • Do not change your dose or stop VIMOVO without first talking to your doctor
  • You may use antacids while taking VIMOVO
  • If you forget to take a dose of VIMOVO, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take 2 doses at one time to make up for a missed dose1
  • If you take more VIMOVO than your doctor recommends, tell your doctor, call the Poison Control Center at 1-800-222-1222, or go to the closest hospital emergency room right away. Symptoms of taking too much VIMOVO may include feeling weak and tired, dizziness, feeling sleepy, upper stomach-area pain or discomfort, heartburn, indigestion or nausea, a change in breathing or stopping breathing, vomiting, bleeding, movements of a body part that you cannot control, coordination problems, and decreased movement


  1. VIMOVO (naproxen/esomeprazole magnesium) [package insert]. Deerfield, IL: Horizon Pharma USA, Inc.; December 2014.